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	This site best viewed at a resolution of at least 1024x768 and a 32 bit color depth.   Welcome to CLM Latest CLM/PML Lab Update Cardiac Troponins Troponins of cardiac origin are regulatory proteins that control the calcium mediated interaction of Actin and Myosin. The troponin complex consists of three subunits: Troponin T, which binds to Tropomyosin and facilitates contractions; Troponin I, which binds to Actin and inhibits Actin/Myosin interaction; and Troponin C, which binds the calcium ions . The amino acid sequence of the skeletal and cardiac isoforms of Troponin T and Troponin I are sufficiently dissimilar and therefore detectable by monoclonal antibody assay. Troponin C is not used clinically because both…  More...   The mission of Consultants in Laboratory Medicine of Greater Toledo is to be the provider of choice in anatomic pathology and laboratory medicine consultative services becoming an essential part of the medical team. We desire to positively impact the delivery of healthcare in the community by providing leading edge, highly relevant and personalized laboratory medicine. These related services are knit tightly with front line physician practice, through application of expert knowledge and information technologies to address present and emerging needs. We provide diagnostic and consultative services with unrelenting passion to provide unsurpassed quality as a valued member of the care giving team.	Medscape Pathology News Mon, 8 Feb 2010 22:42:49 EST A Universal Definition of Myocardial Infarction for the Twenty-First Century Mon, 8 Feb 2010 17:17:25 EST Central to the new universal definition of MI was the use of troponins, determined from serial blood samples. AccessMedicine from McGraw-Hill   Nonalcoholic Steatohepatitis Linked to Increased Mortality Mon, 8 Feb 2010 16:46:56 EST Nonalcoholic steatohepatitis increases the risk for death vs the general population, and liver disease is the third most common cause of death in patients with nonalcoholic fatty liver disease. Medscape Medical News   Management of Acute Poisoning From Medication Ingestion Reviewed Mon, 8 Feb 2010 16:44:28 EST A review suggests that family physicians be familiar with treatment of accidental and intentional medication ingestions and discusses management. Medscape Medical News   Longer Needle May Be Preferred for HBV Vaccination of Obese Teens Mon, 8 Feb 2010 16:35:25 EST In a randomized study, use of a longer needle resulted in significantly higher titers in response to hepatitis B virus vaccine among obese adolescents. Medscape Medical News   Medicare Pay Freeze May Still Leave Physicians in Bad SGR "Fix" Mon, 8 Feb 2010 16:09:43 EST Experts warn that physicians could feel additional financial pain because private insurers often peg their rates to Medicare's. Medscape Medical News
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